Glossary: Psychedelic Medicine
5-MeO-DMT (5-Methoxy-N,N-dimethyltryptamine)
A naturally occurring tryptamine found in certain plants and in the venom of the Sonoran Desert toad. It produces a rapid, intense, and often nonvisual alteration of consciousness characterized by profound ego dissolution and mystical experiences. Its pharmacology differs from that of DMT despite structural similarities.
MDMA (3,4-Methylenedioxymethamphetamine)
An empathogen (entactogen) that increases the release of serotonin, norepinephrine, and dopamine while also promoting oxytocin release. MDMA enhances emotional openness, empathy, trust, and fear extinction and has been extensively studied as an adjunct to psychotherapy for PTSD.
Medication Interaction
A change in the effect or safety of a medication resulting from its interaction with another medication, supplement, food, or psychoactive substance.
Medicine Person
A general term for an Indigenous healer who possesses specialized knowledge of ceremony, healing, spirituality, plants, or traditional medicine. Roles and responsibilities vary considerably among Indigenous cultures.
Mescaline
A naturally occurring classic psychedelic alkaloid found in several cacti, including peyote and San Pedro. Mescaline acts primarily through serotonin 5-HT2A receptors and has been used ceremonially for thousands of years.
Mitragynine
The principal alkaloid in kratom with dose-dependent stimulant and analgesic properties and partial agonist activity at the μ-opioid receptor.
μ-Opioid Receptor
The principal opioid receptor involved in analgesia, reward, respiratory depression, and opioid dependence.






