Glossary: Psychedelic Medicine

One of the two principal endogenous cannabinoids in the human body. 2-AG binds to CB1 and CB2 receptors and plays an important role in pain modulation, immune regulation, appetite, stress responses, and synaptic signaling.

A serotonin receptor widely distributed in the cerebral cortex and the principal receptor responsible for the characteristic effects of classic psychedelics, including altered perception, cognition, emotion, and sense of self.

A naturally occurring tryptamine found in certain plants and in the venom of the Sonoran Desert toad. It produces a rapid, intense, and often nonvisual alteration of consciousness characterized by profound ego dissolution and mystical experiences. Its pharmacology differs from that of DMT despite structural similarities.

A naturally occurring alkaloid present in small amounts in kratom and formed through metabolism of mitragynine. It contributes substantially to kratom's analgesic effects.

A botanical traditionally used to enhance resilience and support the body's ability to adapt to physical, emotional, or environmental stress while promoting physiological balance.

A naturally occurring nitrogen-containing compound found in plants and fungi that often produces significant pharmacological effects.

The cumulative physiological and psychological burden imposed by chronic or repeated stress, resulting in dysregulation across neuroendocrine, immune, metabolic, and autonomic systems and contributing to increased disease risk.

A distinctive red-and-white mushroom used historically in parts of northern Europe and Asia for ceremonial and shamanic purposes. Unlike classic psychedelics, its principal active compounds, muscimol and ibotenic acid, act primarily on GABA receptors and produce dissociative, sedative, and dream-like effects rather than serotonergic psychedelic effects.

An endogenous cannabinoid neurotransmitter whose name derives from the Sanskrit word for 'bliss.' It binds primarily to CB1 receptors and influences mood, pain, appetite, memory, and stress regulation.

Practices that honor, remember, and maintain relationships with deceased ancestors through ritual, prayer, offerings, or ceremony.

A worldview in which animals, plants, landscapes, natural forces, and other aspects of the world are understood to possess agency, spirit, or personhood.

The right of individuals to make informed decisions about their own care based on accurate information and free from coercion.

A traditional Amazonian ceremonial brew typically prepared from Banisteriopsis caapi and Psychotria viridis or other DMT-containing plants. The brew combines DMT with naturally occurring MAO inhibitors (harmine, harmaline, and tetrahydroharmine), making orally administered DMT psychoactive.

The ethical obligation to act in ways that promote the well-being, safety, and welfare of clients or research participants.

The fair and equitable distribution of financial, educational, scientific, or community benefits arising from research, commercialization, or use of traditional knowledge and biological resources.